Behavioural analysis of transgenic mice overexpressing corticotropin-releasing hormone using The Observer and EthoVision. Dirks A, Groenink L, Verdouw M, van der Gugten J and Olivier B
Corticotropin-releasing hormone (CRH) plays a pivotal role in the response of an organism to various stressors. Furthermore, chronic elevated levels of CRH are implicated in human stress-related and affective disorders, including major depression. To gain more insight into the relationship between hyperactivity of the CRH system and associated neuroendocrine, autonomic, physiological and behavioral...